antibody-dependent cytotoxicity

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• Antibody-dependent cell-mediated cytotoxicity — (ADCC) is a mechanism of cell mediated immunity whereby an effector cell of the immune system actively lyses a target cell that has been bound by specific antibodies. It is one of the mechanisms through which antibodies, as part of the humoral… …   Wikipedia

• Antibody-dependent cell-mediated cytotoxicity — An immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody dependent cell mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC. * * * (ADCC), antibody dependent cellular …   Medical dictionary

• Antibody dependent cellular cytotoxicity — Unter ADCC (kurz für antibody dependent cellular cytotoxicity, dt.: Antikörper vermittelte zelluläre Toxizität) versteht man die Reaktion von natürlichen Killerzellen (NK) mit antikörperbeladenen Ziel Zellen (Antigene oder Pathogene). ADCC wird… …   Deutsch Wikipedia

• antibody-dependent cell-mediated cytotoxicity — (ADCC) The killing of antibody coated target cells by cells with Fc receptors that recognize the Fc region of the bound antibody. Most ADCC is mediated by NK cells that have the Fc receptor or CD16 on their surface …   Dictionary of microbiology

• antibody dependent cell-mediated cytotoxicity — (= ADCC) Killing of target cells by lymphocytes or other leucocytes that carry antibody specific for the target cell, attached to their Fc receptors. The cell involved in the killing may be a passive carrier of the antibody …   Dictionary of molecular biology

• Cytotoxicity — is the quality of being toxic to cells. Examples of toxic agents are a chemical substance, an immune cell or some types of venom (e.g. from the puff adder or brown recluse spider). Contents 1 Cell physiology 2 Measuring cytotoxicity …   Wikipedia

• Antibody opsonization — is the process by which a pathogen is marked for ingestion and destruction by a phagocyte. Opsonization involves the binding of an opsonin, i.e., antibody, to a receptor on the pathogen s cell membrane [ [http://cancerweb.ncl.ac.uk/cgi… …   Wikipedia

• cytotoxicity — The quality or state of being cytotoxic. antibody dependent cell mediated c. (ADCC) a form of cell mediated c. that functions by binding of the FC region of IgG antibodies to Fc receptors on leukocytes. The FAB region of the antibody binds to the …   Medical dictionary

• Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… …   Wikipedia

• cell-mediated cytotoxicity — cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody dependent (see antibody dependent cell mediated c.) or independent, as in certain type IV hypersensitivity reactions (q.v.) …   Medical dictionary

• IMMUNITÉ ET SYSTÈME IMMUNITAIRE — Le système immunitaire assume l’une des grandes fonctions physiologiques des Vertébrés: l’aptitude à la reconnaissance d’un nombre prodigieux de structures moléculaires distinctes, les antigènes. Un antigène est classiquement réputé « étranger »… …   Encyclopédie Universelle